Use of Testosterone and Busulfan in the Treatment of Myelofibrosis with Myeloid Metaplasia.
نویسندگان
چکیده
By RIcii nD T. Suxii .n, DAVID E. JENKINS, JR. #{176} AND RALPH L. ENGLE, JR. With the technical assistance of Cynthia Q. Fuller I HE ANEMIA of myelofibrosis with myeboid metaplasia is related to impaired or ineffective erythropoiesis sometimes accompanied by a shortened red blood cell life span.13 The effectiveness of testosterone in stimulating erythropoiesis in patients with myelofibrosis with myeloid metaplasia has been reported in each of nine patients by Gardner and Pringle4 and in six of eight patients by Kennedy.5 Others, however, have not been as successful with such testosterone therapy.#{176}’T The use of busulfan in myebofibrosis with myeloid metaplasia is predicated on its effect upon hematopoietic tissue which results in reducing the size of the spleen and perhaps the liver, thus leading to a decreased rate of hemolysis. Hopefully, the reduction in hemolysis outweighs the suppression of erythropoiesis. In four of eight patients with myeloid metaplasia treated with busulfan, Dameshek et al.8 noted a marked reduction in spleen size, and either improvement or no change in the red blood cell count. In all seven of their patients, Oishi et al.9 reported significant reduction of spleen size, and in all but one, no change or increased value of the hematocrit during busulfan therapy. On the other hand, Korst et al.1#{176} unsuccessfully treated two patients with long courses of busulfan, and Bowdler and Prankerd1t observed no clinical improvement in four patients who had, nevertheless, striking decreases of the white blood cell and platelet counts with doses as small as 2 mg. daily for 5 days. Because of the varying results reported with these drugs, we prepared a protocol to study systematically the effects of these agents in patients with myelofibrosis and myeboid metaplasia.12.13
منابع مشابه
Busulfan therapy in myeloid metaplasia.
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عنوان ژورنال:
- Blood
دوره 23 شماره
صفحات -
تاریخ انتشار 1964